ANALYSIS OF THE CELLULAR BASIS OF MORPHOGENESIS IN VERTEBRATES AND INVERTEBRATES(CELLMOVES, BFU2017-90869-REDT)
Understanding the cellular basis of morphogenesis in animal development is a currentchallenge in basic Biology. Advances in this area will have an important impact onunderstanding congenital defects and on the ability to experimentally recreate and/orregenerate organs. During embryogenesis, organs grow by cell proliferation and undergoextensive remodeling and cell reorganization to acquire the shape and tissue organizationessential for their proper function. Global morphogenetic and cell reorganization eventsemerge from the integration of the behaviors of each single cell in the developing structures. Invertebrates, organ primordia are often composed of thousands/millions of cells andheterogeneous and interactive cellular behaviors take place across organ primodia, making thecomprehensive understanding of organ formation an extraordinary challenge. Undertaking thisanalysis involves new developments in a diversity of areas not frequently met in a singlelaboratory and therefore the coordinated effort of various laboratories greatly acceleratessignificant advances in the field. Here we propose to coordinate a synergic network oflaboratories specialized in the various disciplines involved. The efforts of the network will bedirected to the analysis of two classical mouse organogenesis models; the heart and the limb.We will coordinate activities aimed to the following objectives.