ANALYSIS OF THE CELLULAR BASIS OF MORPHOGENESIS IN VERTEBRATES AND INVERTEBRATES(CELLMOVES, BFU2017-90869-REDT)

Understanding the cellular basis of morphogenesis in animal development is a currentchallenge in basic Biology. Advances in this area will have an important impact onunderstanding congenital defects and on the ability to experimentally recreate and/orregenerate organs. During embryogenesis, organs grow by cell proliferation and undergoextensive remodeling and cell reorganization to acquire the shape and tissue organizationessential for their proper function. Global morphogenetic and cell reorganization eventsemerge from the integration of the behaviors of each single cell in the developing structures. Invertebrates, organ primordia are often composed of thousands/millions of cells andheterogeneous and interactive cellular behaviors take place across organ primodia, making thecomprehensive understanding of organ formation an extraordinary challenge. Undertaking thisanalysis involves new developments in a diversity of areas not frequently met in a singlelaboratory and therefore the coordinated effort of various laboratories greatly acceleratessignificant advances in the field. Here we propose to coordinate a synergic network oflaboratories specialized in the various disciplines involved. The efforts of the network will bedirected to the analysis of two classical mouse organogenesis models; the heart and the limb.We will coordinate activities aimed to the following objectives.

OBJECTIVES

  1. Describe the cellular history of the organs by tracing cell lineages, positions and trajectories at various stages
  2. Generate descriptive 4D computer models that recreate cellular trajectories and display cell behavior parameter maps.
  3. Formulate and test through predictive mathematical model hypotheses on the driving events that trans form cell behavior in morphogenetic events
  4. Experimentally test succesful hypotheses in embryos. To achieve these goals, the proposed networking will bring together experts in Embryology, Optics, Data Analysis, Biophysics and Mathematical Modelling

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Marian Ros

Instituto de Biomedicina y Biotecnología de Cantabria

CSIC – UNIVERSIDAD DE CANTABRIA – SODERCAN

C/ Albert Einstein, 22. 39011 Santander

Tel. + 34 942201933

rosm@unican.es

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